Originally Published: Vol 12, Num 1 (Spring 2024)
Reference Number: 121.002
A method is presented for determining the recombination patterns and phasing in a group of siblings. Two versions of the same basic method are described, one more numerical in nature and the other more visual or graphic. The method requires at least three siblings, preferably four or more, each with an autosomal SNP dataset available, such as those from companies such as Family Tree DNA, 23andMe, or Ancestry. The approach requires for each chromosome, the complete set of matching segments for each sibling pair–the endpoints of the segments along with the type of match (identical on one chromosome of a pair, or identical on both chromosomes of a pair, designated as a “single” or “double” match), plus matching segments for confirmed paternal and maternal second or third cousins. Some examples of recombination in real families will be described, and some general observations on recombination will be summarized.